Print Friendly, PDF & Email

Hepatorenal syndrome (HRS)


Epidemiology of hepatorenal syndrome (HRS)

  • 10% of patients with cirrhosis and ascites.


Pathogenesis hepatorenal syndrome (HRS)

  • Renal vasoconstriction leading to renal failure.
  • The renal vasoconstriction is a compensatory effect of RAAS and ADH, triggered by an extreme underfilling in the arterial circulation.


Types of hepatorenal syndrome (HRS)

  • Type 1
    • Rapidly progressive
    • Triggered by an event such as SBP and requiring urgent intervention
  • Type 2
    •  Occurs gradually, as a consequence of aggravation of end-stage liver disease


Treatment of hepatorenal syndrome (HRS)

  • Plasma expander, normally human albumin solution
  • Terlipressin 0.5-2mg IV four times daily



Click here to download free teaching notes on HRS in the context of decompensated chronic liver disease: Hepatorenal syndrome (HRS)

Perfect revision for medical students, finals, OSCEs and MRCP PACES