Antibodies in rheumatology
- There are always new antibodies with possible associations being found
- There is considerable overlap between many antibodies and their associations e.g. anti-Ro can be found in Sjogrens, SLE and inflammatory myositis
- ANA patterns
- Speckled: SLE, scleroderma, Sjogrens, MCTD
- Homogenous: SLE
- Nucleolar: scleroderma
Condition |
Antibody |
| SLE | Anti-dsDNA |
| SLE | Anti-Sm |
| Drug induced SLE | Anti-histone |
| Sjogrens | Anti-Ro |
| Diffuse cutaneous systemic sclerosis | Anti-scl70 (anti-topoisomerase 1) |
| Limited cutaneous systemic sclerosis | Anti-centromere |
| Myositis | Anti-SRP |
| Anti-synthetase syndrome | Anti-RNA synthetases (Jo-1 most common) |
| Mixed connective tissue disease (MCTD) | Anti u1-snRNP |
| Microscopic polyangiitis | ANCA MPO (pANCA) |
| Polyarteritis nodosa (PAN) | ANCA MPO (pANCA) |
| Granulomatous polyangiitis | ANCA PR3 (cANCA) |