Home
Print Friendly, PDF & Email

­­

Hepatosplenomegaly

 

Aetiology of hepatosplenomegaly

  • Chronic liver disease and portal hypertension
    • (see chronic liver disease section for further differentials)
  • Haematological disease:
    • Leukaemias
    • Lymphomas
    • Myelofibrosis
    • Myeloproliferative disease
      • Essential thrombocytopenia, polycythaemia, primary myelofibrosis, CML
    • Haemolytic anaemias
      • Hb disorders: Thalassaemia, sickle cell disease (eventually leads to splenic atrophy)
      • Red cell structure: Spherocytosis/elliptocytosis
      • Enzyme: G6PD deficiency, pyruvate kinase deficiency
  • Infection:
    • Acute viral hepatitis
    • EBV, CMV
    • Foreign/tropical
      • Malaria
      • Leishmaniasis
  • Connective tissue disease
    • SLE
    • Amyloidosis
    • Sarcoidosis
  • Metabolic disease:
    • Niemann Pick disease
    • Gaucher’s disease

 

 History in hepatosplenomegaly

  • Presenting complaint
    • Abdominal swelling
  • History of presenting complaint
    • Abdominal pain
    • Bloating
    • Abnormal bruising/bleeding
    • Pruritus
    • Constitutional symptoms: weight loss, night sweats, fever
  • Past medical history
    • Previous EBV
  • Medications
    • Hepatotoxic medications
  • Family history
    • Malignancy
    • Connective tissue disease
    • Metabolic disorders
  • Social history
    • Travel history
    • Alcohol consumption
    • Smoking

 

 Examination of hepatosplenomegaly

  • Hepatosplenomegaly
  • Signs of chronic liver disease
  • Lymphadenopathy
  • Anaemia

 

 Initial investigation of hepatosplenomegaly

 

Click here for medical student OSCE and PACES questions about hepatosplenomegaly

Common hepatosplenomegaly exam questions for medical students, finals, OSCEs and MRCP PACES

 

Click here to download free teaching notes on hepatosplenomegaly: Hepatosplenomegaly

Perfect revision for medical students, finals, OSCEs and MRCP PACES