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Lewy Body Dementia (LBD or DLB)

  • Named after Frederic Lewy
  • Characterised by the presence of Lewy Body-like inclusions within neurones
  • Gradual death and decline of brain cells
  • Low-levels of acetylcholine and dopamine observed
  • Symptoms
    • Akin to a combination of Alzheimer’s and Parkinson’s Disease
    • Marked fluctuation may occur throughout the day
    • Disrupted sleep patterns
    • Hallucinations (particularly visual)
    • Parkinsonism movement disorders, but less-susceptible to treatment with L-Dopa
  • Diagnosis is clinical, though the classical distinguishing features (hallucinations etc…) may not always be present
    • Can be difficult to distinguish LBD from Alzheimer’s with Parkinson’s Disease


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