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 Common hepatosplenomegaly exam questions for medical finals, OSCEs and MRCP PACES


Question 1. 

What are the haematological causes of hepatosplenomegaly?

  • Leukaemias (AML, CML, ALL, CLL)
  • Lymphomas
  • Myelofibrosis
  • Myeloproliferative disease
    • Essential thrombocytopenia, polycythaemia, primary myelofibrosis, CML
  • Haemolytic anaemias
    • Hb disorders: Thalassaemia, sickle cell disease (eventually leads to splenic atrophy)
    • Red cell structure: Spherocytosis/elliptocytosis
    • Enzyme: G6PD deficiency, pyruvate kinase deficiency

See questions on hepatomegaly and splenomegaly for further questions